Tuesday, May 31, 2011
My baby is on world stage
Friday, February 11, 2011
Need more songs like this
Do you ever feel like a plastic bag,
drifting through the wind
wanting to start again?
Do you ever feel, feel so paper thin
like a house of cards,
one blow from caving in?
Do you ever feel already buried deep?
6 feet under screams but no one seems to hear a thing
Do you know that there's still a chance for you
'Cause there's a spark in you
You just gotta ignite, the light, and let it shine
Just own the night like the 4th of July
'Cause baby you're a firework
Come on, show 'em what you're worth
Make 'em go "Oh, oh, oh"
As you shoot across the sky-y-y
Baby, you're a firework
Come on, let your colors burst
Make 'em go "Oh, oh, oh"
You're gonna leave 'em all in awe, awe, awe
You don't have to feel like a waste of space
You're original, cannot be replaced
If you only knew what the future holds
After a hurricane comes a rainbow
Maybe your reason why all the doors are closed
So you could open one that leads you to the perfect road
Like a lightning bolt, your heart will glow
And when it's time, you'll know
You just gotta ignite, the light, and let it shine
Just own the night like the 4th of July
'Cause baby you're a firework
Come on, show 'em what you're worth
Make 'em go "Oh, oh, oh"
As you shoot across the sky-y-y
Baby, you're a firework
Come on, let your colors burst
Make 'em go "Oh, Oh, Oh"
You're gonna leave 'em all in awe, awe, awe
Boom, boom, boom
Even brighter than the moon, moon, moon
It's always been inside of you, you, you
And now it's time to let it through-ough-ough
'Cause baby you're a firework
Come on, show 'em what you're worth
Make 'em go "Oh, Oh, Oh"
As you shoot across the sky-y-y
Baby, you're a firework
Come on, let your colors burst
Make 'em go "Oh, Oh, Oh"
You're gonna leave 'em all in awe, awe, awe
Boom, boom, boom
Even brighter than the moon, moon, moon
Boom, boom, boom
Even brighter than the moon, moon, moon
Monday, January 24, 2011
An Apple convert
After buying the iPhone 4, I also bought a 21.5" iMac on the same day of Dec 27. I was inclined to buy a MacBook Pro for its portability and to process my travel pictures. However, after some brainwashing by Thaddeus, I decided to go for iMac since at the same price, the iMac had much higher specifications than a MacBook. The wireless keyboard and mouse are a plus feature for aesthetics and the fast start-up and shut down win hands down over Windows. Most importantly, Mac system has few malicious virus programs compared to Windows. Sunday, January 23, 2011
Reverse Culture Shock
Tuesday, January 11, 2011
A brand new year with brand new experiences
Thursday, November 25, 2010
Crazy last weeks
I had to play catch up with work, meeting up with friends to bid farewell, and tying loose ends before returning home on Dec 6.
On top of that, my junior just arrived, so I drove him and my new housemate around to buy stuffs.
Finally on Nov 24, I had the chance to sit down at lab without going anywhere or doing anything! A good gift for myself.
Wednesday, October 20, 2010
Reflecting on my past 5-year professional experience
However, before I switched to a wet-laboratory from a bioinformatics background, I had set my goal of publishing at least two first authors during my stint here.
Writing has been a difficult process for me. It takes a lot of mental discipline and emotional detachment to churn out a good article.
My first research paper took slightly more than a year to get it published. My second review paper had a shorter period of seven months, from mentally accepting the invitation to write for the journal to publishing it. I am happy on fulfilling my goal.
All said and done, I am grateful to my boss, Professor Thomas August for believing in my conviction and fellow colleagues in getting the papers published!
Highly conserved influenza A sequences as T cell epitopes-based vaccine targets to address the viral variability
Paul ThiamJoo Tan, Asif M. Khan and J. Thomas August
Volume 7, Issue 4April 2011
Vaccines are the only proven effective method for prevention of human infectious diseases. Almost all traditional vaccines require activating immunological memory B cells to secrete neutralizing antibodies against invading pathogens. The complication with influenza viruses is the high viral mutation rate that results in immune escape through modification of the B cell epitopes. Studies of T cell immunity to influenza infection provide an alternative vaccine strategy based on highly conserved T cell epitopes. In this review, we discuss the importance of T cell-mediated immunity in influenza infection and the need for a targeted vaccine approach focused on highly conserved T cell epitopes to mitigate immune escape. We propose 15 highly conserved pan-influenza sequences as possible T cell epitopes-based vaccine targets for broad protection and lasting immunity against variant influenza strains.
Friday, September 17, 2010
Shooting at Johns Hopkins Hospital
Sometime after 11am, I received an email from Hopkins saying that someone had fired a shot inside the hospital building. Employees were advised to stay behind locked rooms.
From my laboratory, I could hear siren and saw a police helicopter hovering above the East Baltimore Campus.
Roads surrounding the hospital were closed. Vehicles used by SWAT teams, police and firefighters formed a blockage where the shooting happened. Media groups were swarming around the cordoned area.
The shooter, who became emotionally distraught after hearing his mother's condition, had shot the consulting physician. Eventually, he turned on his mother and himself. The wounded doctor survived.
Just a sad day!
Thursday, August 12, 2010
Celebrating over 100,000 views
Thank you for your viewership and downloads. Looking back on my 73 albums, my photography skill has improved in these four years. Initially, I had joined to upload my pictures onto a server as a backup. Never had I imagined that any of my pictures would be featured as Picture Of The Day (POTD) since I was an amateur photographer nor a premium Webshots member.
I still prefer to take landscape or still pictures. My next venture will likely be night scene. Taking people is not my forte but no harm trying out.
You can enjoy my work at Littlesaul.
Sunday, August 01, 2010
Reflection
Postings, henceforth, maybe few and far between, but will highlight crucial events.
After my last publication on influenza A, entitled "Conservation and Diversity of Influenza A H1N1 HLA-Restricted T Cell Epitope Candidates for Epitope-Based Vaccines", I was invited to write a peer review on T cell epitope-based vaccines which I believe is the next frontier in vaccine development.
I consulted with my boss, Prof. August and we agreed to go ahead. Reading through over 100 research articles was tough. I also under-estimated the huge amount of time needed to write.
The four-month period leading to submission in July was a trying period for me which explained the absence of postings. I felt liberated after my submission.
Today, a month later, I got the answer back from the reviewers. As usual, we had to revise or rebut the reviewers' comments. With something to work on, it will be easier than writing from scratch.
Tuesday, April 20, 2010
Sleepless poems
Each night, my sleep is interrupted.
Yawning, concentration is affected.
Mistakes are committed.
Dozing, tired man
Catching up with sleep.
The Elusive Sleep
Each night, I prepared for our meeting
Body and dental hygiene a must,
A clean set of PJ, nothing fanciful.
Our meeting agreement involved lying still,
muscles relaxing and natural breathing.
A blank mind I tried to maintain.
Anxiety, anger, depression, worries, etc.
Negative feelings are not
Appreciated by my guest.
Atlas, I grew impatient.
For she had stood me up again.
I lie awake,
Thinking of The Elusive Sleep.
Thursday, March 25, 2010
Bad sleeping posture = Bad neck ache
I was worried that it could be more than a bad strain and visited my sports doctor. He diagnosed as a strain to my right trapezius muscle and advised me to go for physical therapy. Trapezius muscle is a huge muscle group, consisting of a broad, flat muscle on each side of the upper and back part of the neck, shoulders, and back. This muscle group is involve in raising, rotating, or drawing back the shoulders, and pulling the head backward or to one side.
Since I had never been to a physical therapy before, it would be interesting to determine how they would treat the pain. Prior to treatment, I need to fill up a survey to describe my pain level, types of pain (I did not know there were so many adjectives to describe pain, amazing) and usual health questions.
I was given an ultrasound and massage over the muscle. My therapist could feel the tightness of my muscle whereas I just felt pain. She also taught me to sleep correctly by adjusting the height of my pillows or rolling a towel to support my neck. The position to adopt is the natural curvature of the spine, not too high where you would be facing your toes nor too low, causing the neck to arch up. The shoulders should not be rested on the pillows. When I first came to USA, I had trouble adjusting to the soft pillows and the low height. So, I had five pillows to play with the height. She also printed out some neck exercises to stretch the muscles.
I just bought a contour memory foam pillow which has the neck support. The cover was soft and plush, really comfortable. If I maintain to sleep on my back, I am on the road to recovery.
Wednesday, March 10, 2010
Hot sauces
I, a fan of spicy food, was drawn to try out the hottest things available. While watching a program on Travel Channel, I got to know of two hot sauces. One is 911 from Cluck-U Chicken which according to the sauce meter (left picture) is 151 degree. (FYI, 911 is an emergency number in USA, synonymous to 999 in Singapore.) Before customers could taste or buy the 911 sauce, they had to agree and consent to a waiver release. I bought a 5 oz bottle at $10.60. It was spicy but leave a bitter aftertaste like when I apply cayenne pepper powder to my food.
The second was Atomic Wing Sauce, sold by Quaker Stake & Lube. As the nearest store is 4 hour drive away, I had not tried this sauce. It is available online, selling at $5.99 for 2 fl. oz. The Scoville Heat Rating is 150000. A waiver release is also required.
The one I like so far is Hotter Hot Sauce by Texas Pete which is available in the local supermarket. It is spicier than the Original Hot Sauce which is mild to me. Further, there is no bitter aftertaste. Some people may find this preposterous. I would apply a few drips on each potato chip before eating the chip.There is a shop in Delaware for fans of hot sauces. It carries a wide variety of sauces from all over the world. If I remembered correctly, it is owned by a brother and sister. I am trying to locate it. I saw it on Travel Channel. Anyone know this?
Tuesday, January 26, 2010
A new way of sauteing
Nowadays, I add oil and saute onions with a lid covered to prevent oil splattering and frying odor from getting on my clothes in the closet. Plus, I could add broth to simmer meat. The less messy it is, the better for me. Yipee.
Monday, January 18, 2010
Another uniquely place
Wednesday, January 13, 2010
Update to my knowledge of exercising
A few weeks ago, I ordered a book called "The Men's Health Big Book of Exercises: Four Weeks to a Leaner, Stronger, More Muscular YOU!" I felt that my old routine of exercises was boring since it had not changed for 4 years and my muscle growth had plateaued. After reading Chapter 2 on FAQs on lifting, I realized my knowledge on sets and repetitions of workout was outdated. The 619 exercises, including warm-up exercises which I often neglect, will keep me occupied.
The weather forecast for the next 7 days should be above freezing, time to head out and burn calories.
Friday, January 08, 2010
New Mexico Dec 9-12
Fast forward to 9 Dec 2009, I booked a Delta flight to Albuquerque Airport from Baltimore-Washington International (BWI) Airport as traveling over Christmas and New Year period cost more. On my first leg from BWI to Atlanta for my transit, I was upgraded to first class. This was the first time that I sat in this section. The perks of sitting in first class included checking in my winter coat and the flight attendant started to serve me drinks the moment I sat down. There was plenty of seat space for me to cross my legs if I wished. It was definitely a pampering experience. For my connecting flight to Albuquerque, I was back to economy class.
After picking up my rental car, I drove northeast towards Santa Fe which served as my base for visiting other vicinities. I was advised by the car rental staff to upgrade to a Toyota Camry from an economy car as New Mexico was hit by a snowstorm, resulting in icy roads and the highway speed limit was 75 mph. Usually it is 65 mph. An economy car would 'shake' and be hard to control at 75 mph. After upgrading and buying liability insurance and a full fuel tank, I had to pay $200+ on top of what I had paid for in my Travelocity package.
It took me about 1.5 hour to reach Santa Fe around 4pm. Sure enough, the road was icy and I did not regret spending the extra cash on safety. As I had not taken any meal since morning, I proceeded to Santa Fe Plaza where most restaurants were situated. My hotel, Sage Inn, provided free transport to the plaza where I headed to a Thai restaurant but it was closed. Then, I walked towards Burro Alley where I dined at Cafe Paris Restaurant and Bakery. Burro Alley used to be a nightlife district for the city and is named after the small donkeys which carried firewood to be sold here.
After fulfilling my hunger, I toured around the 400-year old Plaza, visiting St Francis Cathedral, Loretto Chapel and La Fonda Hotel. Most shops were closed around 5pm as this was off-peak season. The Loretto Chapel had an interesting history. The small Gothic Chapel was built in the 1870s without a staircase to the choir loft from the ground. Many builders were consulted to solve the predicament with the intention of building a staircase that would not take up too much space. Most suggested using a ladder or reconstructing the balcony. The Sisters of Loretto prayed a Novena to Saint Joseph and on the ninth day, a mysterious carpenter came forward and built a circular stairway to the loft. The stairway makes two 360-degree turns with no center nor side support and no nails. Just plain wooden pegs. Upon completing the stairway, the carpenter disappeared without asking payment for his work. This stairway has been attributed to Saint Joseph's work and is called the Miraculous Stairway.
The next day, I drove northeast to Taos where I visited Taos Pueblo, a UNESCO World Heritage Site and a National Historic Landmark. This place has been continuously inhabited by the Native American Indians for over 1000 years. The buildings are made of adobe which is earth mixed with water and the walls are really thick, at least 10 inches wide. To see the interior, you can visit the shops located within the community where the walls are usually painted white. There is no modern amenity, specifically electricity and water, in this community. Thus, there is a fireplace inside for cooking and keeping warm. The river running through the village serves as their source of drinking water. They have a majestic view of Taos Mountain where the natives considered it sacred and performed religious ceremonies there.
For the truly environmentally friendly people, there is a community not far from Taos who live in structures made out of earth and recycled materials such as glass bottles, aluminum cans, and car tires. The Earthship Biotecture Headquarter Visitor Center is a self-sufficient housing using solar energy and integrated water system, including its own garden. Precipitation is collected where water is used 4 times before releasing back into the environment. Visit Earthship Biotecture for more information.
On my third day, I drove to Bandelier National Monument, home to Ancestral Pueblo dwellings. Along the way, I was glad to explore White Rock because the scenery from the outlook was fantastic. There was a partially frozen waterfall and a gorge. Usually, being a planner, I would have drove on towards my target. But I learned my lesson when I went to Cape May, New Jersey. Then, I saw a country rodeo along the way and I thought it would be there on my way back. Well, the place was deserted on my return trip.
After getting back to my actual route, I drove for many miles alone with no car in sight on New Mexico Route 4. According to my GPS, I should have reached the park entrance. I pressed on and finally saw the entrance. A self-guided tour is available at the Main Loop Trail with many Ancestral Pueblo dwellings, carved out from cliff walls. One could climb up ladders to the cavates. At 5' 10", it was difficult for me to stay in the carved units.
Another attraction at Bandelier National Monument was The Alcove House, formerly called Ceremonial Cave, which is 140 feet up a cliff wall. Getting there involves climbing 4 steep wooden ladders and stone stairs. Due to the snowstorm, the Alcove House was closed for safety reasons.
With night falling, I headed back to Santa Fe and toured along Guadalupe Street, taking pictures of murals, and going into art galleries to escape from the cold. That night, I was fortunate to witness a local event where there was a procession starting from St Francis Cathedral to Our Lady of Guadalupe Church. I joined in the procession while photographing the entire event. There were devotees singing hymns, carrying the statue and picture of Our Lady of Guadalupe, and musicians playing instruments.
For my last stop, I had about 2 hours to tour Old Albuquerque. It seemed that all the towns in New Mexico had a centralized place called the plaza where people meet. The impression I got after visiting Santa Fe, Taos, and Old Albuquerque was that there were a lot of Native American artwork selling similar things and lots of art galleries. My whole being was saturated with arts every time I visited the plaza. I managed to take a brisk walk around the sculpture garden of the Albuquerque Museum of Art and History.
After returning the car, my itinerary was to fly to Salt Lake City and then to Baltimore. For the second leg, I was once again upgraded to first class and had a relaxing time. Dinner was chicken Parmesan, salad, and pumpkin pie. De-li-cious!
New Mexico photo album
Friday, January 01, 2010
2010
Keeping up with traditions, my new year resolutions are:
- Go on a marvelous, scary and fulfilling journey: Self-discovery.
- Find a job.
- Watch less tv.
Tuesday, December 29, 2009
Travel Channel showcasing Singapore
The sweep started on November 1, 2009 at 12:00 a.m. Eastern Time ("ET") and ends on December 31, 2009 at 11:59 p.m. ET. I have not been entering for the sweep daily. Just a few more days and I hope that I am a lucky fellow.
It would be fun for the winner to experience Singapore, with its diverse culture, food, cleanliness, and low crimes.
Friday, December 25, 2009
The snow blizzard on Dec 19, 2009
By morning, the scenery was transformed overnight into a wintry snowscape, though officially, the Winter Solstice began on Dec 21 at 12.47 pm EST.
Initially, it felt kind of romantic with pretty snowflakes falling as I looked out from my warm apartment. However, as it continued to snow without abate and gusty wind picking up, it became scary. Cars were sliding on roads and pedestrians had to walk in knee-deep snow. This was the longest snow storm I had experience since I was here.
By Sunday Dec 20, the blizzard had stopped and everything was covered in snow. My balcony had snow dunes where it was 9 inches at the highest dune.
A cool idea struck me and I began building my first snowman, Feisty with the snow on the balcony. The snow was very dry, not conducive for make a snowball, let alone, a snowman. To overcome this, I sprayed water on the snow as I built. Ideally, you would need to form a snowball initially and then roll the ball around in sticky/wet snow. Imagine animation of cartoon characters rolling down a slope and forming a large snowball.
In this case, I made two snowballs, one for the body and the other for the head. I sat the body on a chair and added snow to it, layer by layer after spraying with water to cement the dry snow. After building the body to a sizable scale, I flatten the top of the body to place the second snowball and started working on the head. Since I had no carrot for its nose, I compressed some snow into a rod and stuck it in. The mouth was a red chilli, eyes were star aniseed, and buttons were dried flower pods from a potpourri. Instead of bundling it up with my cashmere scarfs, as pointed out by Charlene, I used two rags. To complete the look, Feisty, as I called it, was decorated with various hats (see Snow Blizzard album).
Then, I went outside, armed with a measuring tape to measure snow accumulation of the storm. The deepest was at 26 inches. There was this car, completely covered in snow but had a clearing on its driver's side, carved out by wind.
As the snow was deep, I could not resist making snow angels. The last time I made a snow angel, my jeans got dirty because the snow was not deep enough. Not this time, it was 13 inches deep.
I proceeded towards Sherwood Garden to take wintry pictures. Along the way, I saw private house owners busy shoveling their walkways or digging cars out. There were children sledding down a slope.
Five days later after the storm, Feisty was fighting to stay frozen. It needed some nose job and half its head was deformed. Things were falling apart. Well, as the saying goes, when a door closes, another opens. A row of icicles were hanging from the roof which looked fantastic. Let's see how long Feisty is going to last.
Blessed Christmas to you and wishing you joy, health and peace in 2010.
Snow Blizzard album